A129 Sigma


Synonym: 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine

  • CAS Number 14028-44-5

  • Empirical Formula (Hill Notation) C17H16ClN3O

  • Molecular Weight 313.78

  •  MDL number MFCD00069210

  •  PubChem Substance ID 24278075



Biochem/physiol Actions

Tricyclic antidepressant; inhibits uptake of norepinephrine; inhibits 5-HT2 serotonergic receptors.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A129.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

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Safety Information

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Protocols & Articles


Piperazines - Aldrich ChemFiles 2005, 5.5, 1.

Sigma-Aldrich is pleased to offer the third installment of our Privileged Structures ChemFiles. This piece will focus on the piperazine scaffold. We will discuss application data, Sigma-Aldrich build...
Aldrich ChemFiles 2005, 5.5, 1.
Keywords: Anti-depressants, Antifungals, Antivirals, Building blocks, Medicinal chemistry, Metabolism, Organic synthesis, Pharmaceutical

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