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A1719 Sigma

Monoclonal Anti-Activin A βA subunit antibody produced in mouse

clone 69403.11, purified immunoglobulin, lyophilized powder

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Properties

Related Categories AC-AC, Activins, Activins and Inhibins, Alphabetical Index, Antibodies,
conjugate   unconjugated
clone   69403.11, monoclonal
biological source   mouse
application(s)   capture ELISA: suitable
  neutralization: suitable
species reactivity   human
form   lyophilized powder
storage temp.   −20°C
antibody form   purified immunoglobulin
isotype   IgG1
antibody product type   primary antibodies
recombinant   expressed in mouse cell line
UniProt accession no.   P08476
Gene Information   human ... INHBA(3624)

Description

General description

Activins are members of the TGF-β family. Activins are dimeric proteins composed of 2 beta subunits. Acitivn A contains 2 β A subunits. Activins bind to the Type II Activin receptor triggering phosphorylation of Type I Acitivn receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis.

Monoclonal anti-activin A βA subunit antibody can neutralize the bioactivity of recombinant human activin A. It also recognizes activin A precursors. Furthermore, the antibody binds to activin A βA subunit and inhibin A βA subunit by capture ELISA.

Immunogen

mature recombinant human activin A.

Application

Monoclonal anti-activin A betaA subunit is suitable for use in capture ELISA and neutralization assays.

Physical form

Lyophilized from a solution of phosphate buffered saline with 5% trehalose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Preparation Note

Purified using protein G

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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