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A1719 Sigma

Monoclonal Anti-Activin A βA subunit antibody produced in mouse

clone 69403.11, purified immunoglobulin, lyophilized powder

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Properties

Related Categories AC-AC, Activins, Activins and Inhibins, Alphabetical Index, Antibodies,
species reactivity   human
application(s)   capture ELISA: suitable
  neutralization: suitable
clone   69403.11, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG1
storage temp.   −20°C
Gene Information   human ... INHBA(3624)
biological source   mouse
recombinant   expressed in mouse cell line
conjugate   unconjugated

Description

Immunogen

mature recombinant human activin A.

General description

Activins are members of the TGF-β family. Activins are dimeric proteins composed of 2 beta subunits. Acitivn A contains 2 β A subunits. Activins bind to the Type II Activin receptor triggering phosphorylation of Type I Acitivn receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis.

Monoclonal anti-activin A βA subunit antibody can neutralize the bioactivity of recombinant human activin A. It also recognizes activin A precursors. Furthermore, the antibody binds to activin A βA subunit and inhibin A βA subunit by capture ELISA.

Physical form

Lyophilized from a solution of phosphate buffered saline with 5% trehalose

Preparation Note

Purified using protein G

Application

Monoclonal anti-activin A betaA subunit is suitable for use in capture ELISA and neutralization assays.

Price and Availability


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Safety & Documentation

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
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References

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