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A1895 Sigma-Aldrich

Aurintricarboxylic acid

practical grade, ≥85% (titration), powder

Synonym: ATA

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, DNA Repair Regulators, DNA metabolism More...
grade   practical grade
assay   ≥85% (titration)
form   powder
application(s)   hematology: suitable
  histology: suitable
color   dark red to brown
mp   300 °C (lit.)
solubility   1 M NH4OH: 10 mg/mL
Featured Industry   Diagnostic Assay Manufacturing
storage temp.   room temp
SMILES string   OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
InChI   1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
InChI key   GIXWDMTZECRIJT-UHFFFAOYSA-N

Description

Application

• Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.
• It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).
• It has been used as a ribonuclease inhibitor.

Packaging

5, 25 g in glass bottle

Biochem/physiol Actions

Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
GU4790000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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