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A211130 Sigma-Aldrich

DMT-2′O-Methyl-rA(bz) Phosphoramidite

configured for ABI

Synonym: DMT-2′-O-Me-rA(bz) amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

  • CAS Number 110782-31-5

  • Empirical Formula (Hill Notation) C48H54N7O8P

  • Molecular Weight 887.96

  •  MDL number MFCD00792622

  •  PubChem Substance ID 329770742

  •  NACRES NA.51

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Properties

Related Categories Chemical Synthesis, DMT-2′O-Methyl-rA(bz) Phosphoramidite, Phosphoramidites and Reagents for Oligonucleotide Synthesis (Proligo Reagents), RNA Phosphoramidites, Standard Deprotected 2′O-Methyl RNA Phosphoramidites More...
biological source   non-animal source (no BSE/TSE risk)
product line   Proligo Reagents
assay   ≥99% (31P-NMR)
  ≥99.0% (reversed phase HPLC)
  conforms (1H-NMR)
  conforms (LC/MS)
form   powder
application(s)   oligo synthesis: suitable
impurities   ≤0.1% single unspecified Impurity (reversed phase HPLC)
  ≤0.3% mA2 (reversed phase HPLC, Hydrolysate)
  ≤0.3% mA3 (reversed phase HPLC, DMT-rA(bz)me)
  ≤0.3% water content (Karl Fischer)
  ≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
  ≤1.0% mA1 (reversed phase HPLC, DMT-rA(bz)me-DMT)
  ≤3% residual Solvent content
color   white to off-white
λ   conforms (UV/VIS Identity)
compatibility   configured for ABI
nucleoside profile   base: adenosine
base protecting group: benzoyl
2' protecting group: methyl
5' protecting group: DMT
deprotection: standard
storage temp.   2-8°C
SMILES string   CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c3ccc(OC)cc3)c4ccc(OC)cc4)O[C@H]1n5cnc6c(NC(=O)c7ccccc7)ncnc56
InChI   1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1
InChI key   AZCGOTUYEPXHMJ-PSVHYZMASA-N
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

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