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  • A2169 - 3′-Azido-3′-deoxythymidine

A2169 Sigma-Aldrich


≥98% (HPLC)

Synonym: AZT, Azidothymidine, ZDV, Zidovudine

  • CAS Number 30516-87-1

  • Empirical Formula (Hill Notation) C10H13N5O4

  • Molecular Weight 267.24

  •  Beilstein/REAXYS Number 3595791

  •  MDL number MFCD00006536

  •  PubChem Substance ID 24278143

  •  NACRES NA.77



Related Categories AIDS and Viral Research Reagents, AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
assay   ≥98% (HPLC)
form   powder
mp   113-115 °C (lit.)
solubility   H2O: 50 mg/mL
storage temp.   −20°C
SMILES string   CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI   1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
Gene Information   human ... HIVE1(3095)
mouse ... Slc29a1(63959)



3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration and as an antimicrobial agent to evaluate its anti-Salmonella activity.


1 g in glass bottle

100, 250 mg in glass bottle

25 mg in glass insert

Biochem/physiol Actions

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.

Reverse transcriptase inhibitor active against HIV-1 virus.

Features and Benefits

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This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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