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A2504 Sigma-Aldrich

6-Aminocaproic acid

≥99% (titration), powder

Synonym: ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA

  • CAS Number 60-32-2

  • Linear Formula H2N(CH2)5CO2H

  • Molecular Weight 131.17

  •  Beilstein/REAXYS Number 906872

  •  EC Number 200-469-3

  •  MDL number MFCD00008238

  •  PubChem Substance ID 24890662

  •  NACRES NA.77

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Properties

Related Categories A to C, Biochemicals and Reagents, Chymotrypsin, α-, Chymotrypsin, alpha-, Coagulation Proteins and Reagents,
Quality Level   200
biological source   synthetic
assay   ≥99% (titration)
form   powder
color   white
mp   207-209 °C (dec.) (lit.)
solubility   H2O: 50 mg/mL
SMILES string   NCCCCCC(O)=O
InChI   1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChI key   SLXKOJJOQWFEFD-UHFFFAOYSA-N
Gene Information   human ... PLAT(5327), PLG(5340)
rat ... Ppm1a(24666)

Description

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Packaging

1 kg in poly bottle

25, 100, 500 g in poly bottle

5 kg in poly drum

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MO6300000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles
Peer-Reviewed Papers
15

References

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