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A2661 Sigma-Aldrich

Acetylcholine chloride

suitable for cell culture

Synonym: ACh

  • CAS Number 60-31-1

  • Linear Formula (CH3)3N+CH2CH2OCOCH3Cl-

  • Molecular Weight 181.66

  •  Beilstein/REAXYS Number 3571875

  •  EC Number 200-468-8

  •  MDL number MFCD00011698

  •  eCl@ss 32190102

  •  PubChem Substance ID 24890686

  •  NACRES NA.75

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Properties

Related Categories Analytical and Industrial Enzymes, Biochemicals and Reagents, Cell Biology, Cell Culture, Cholinesterase Substrates,
Quality Level   400
biological source   synthetic
assay   ~99%
form   powder
application(s)   cell culture | mammalian: suitable
mp   146-150 °C (lit.)
solubility   water: 100 mg/mL, clear, colorless
shipped in   ambient
storage temp.   room temp
SMILES string   [Cl-].CC(=O)OCC[N+](C)(C)C
InChI   1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChI key   JUGOREOARAHOCO-UHFFFAOYSA-M
Gene Information   human ... CHRM3(1131)

Description

Application

Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
FZ9800000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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