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  • A2851 - Anti-ADAM-10, Prohormone Convertase Activation Site antibody produced in rabbit

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A2851 Sigma-Aldrich

Anti-ADAM-10, Prohormone Convertase Activation Site antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Anti-A Disintegrin And Metalloproteinase-10, Anti-Kuzbanian, Anti-MADM

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Description

General description

ADAM is a member of the disintegrin and metalloproteinase family of proteins which possess both adhesion and zinc protease functions. ADAM-10 is a sheddase with both a secreted and membrane-bound form. ADAM-10 null mice are embryonically lethal with neural and cardiac defects. Rabbit anti-ADAM-10 antibody can localize human ADAM 10 and does not detect other ADAMs.

Recognizes the furin cleavage site (58-60 kDa) of ADAM-10. Detects the latent form of the enzyme.

Immunogen

synthetic peptide corresponding to the prohormone convertase (PC) cleavage site of human ADAM-10.

Application

Rabbit anti-ADAM-10 antibody has been used for western blot assays.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Packaging

100 μg in glass bottle

Safety & Documentation

Safety Information

WGK Germany 
1

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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