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A3401 Sigma-Aldrich

Ala-Ala-Phe-7-amido-4-methylcoumarin

protease substrate

  • CAS Number 62037-41-6

  • Empirical Formula (Hill Notation) C25H28N4O5

  • Molecular Weight 464.51

  •  MDL number MFCD00070149

  •  PubChem Substance ID 24890766

  •  NACRES NA.32

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chymotrypsin, alpha, Enzyme Substrates,
storage temp.   2-8°C
SMILES string   CC(N)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI   1S/C25H28N4O5/c1-14-11-22(30)34-21-13-18(9-10-19(14)21)28-25(33)20(12-17-7-5-4-6-8-17)29-24(32)16(3)27-23(31)15(2)26/h4-11,13,15-16,20H,12,26H2,1-3H3,(H,27,31)(H,28,33)(H,29,32)
InChI key   FVRLYIFIDKXFHU-UHFFFAOYSA-N

Description

General description

Ala-Ala-Phe-7-amido-4-methylcoumarin is a fluorogenic substrate for the proteolytic activity. It is a positively charged substrate molecule.

Application

Ala-Ala-Phe-7-amido-4-methylcoumarin has been used:
• in the preparation of the reaction mixture for enzymatic assays
• to initiate the enzyme reaction in tripeptidyl peptidase-1 (TPP1) enzyme activity assay
• to initiate the assay reaction in lysosomal hydrolases activity assay

Substrates

Substrate for chymotrypsin and tripeptidyl peptidaseII.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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