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A3487 Sigma-Aldrich

Clarithromycin

≥98% (HPLC)

  • CAS Number 81103-11-9

  • Empirical Formula (Hill Notation) C38H69NO13

  • Molecular Weight 747.95

  •  MDL number MFCD00865140

  •  PubChem Substance ID 329770825

  •  NACRES NA.85

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Properties

Quality Level   200
biological source   synthetic
assay   ≥98% (HPLC)
form   powder
color   white to faint yellow
solubility   DMSO: 1 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C
SMILES string   O[C@@H]([C@@](O)(C)[C@@H](CC)OC([C@H](C)[C@H]1O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)=O)[C@@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]1C)=O
InChI   1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChI key   AGOYDEPGAOXOCK-KCBOHYOISA-N

Description

Application

Clarithromycin has been used to study its effect on the potassium channel KCNJ5WT.

Biochem/physiol Actions

Clarithromycin is stable in gastric acid.

Clarithromycin possess bactericidal activity including anti-mycobacterial activity against Mycobacterium leprae, and M.avium complex.

Clarithromycin is a macrolide antibiotic that interferes with bacterial protein synthesis. Clarithromycin is an acid-stable version of erythromycin and is particularly effective against Gram-negative bacteria. It has a short half-life, however its metabolite, 14-hydroxy clarithromycin is nearly twice as active as clarithromycin against certain bacteria.

Packaging

100mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
KF4997000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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