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A3650 Sigma-Aldrich

Amikacin hydrate

aminoglycoside antibiotic

Synonym: N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A

  • CAS Number 1257517-67-1

  • Empirical Formula (Hill Notation) C22H43N5O13 · xH2O

  • Molecular Weight 585.60 (anhydrous basis)

  •  Beilstein/REAXYS Number 1445422

  •  EC Number 253-538-5

  •  MDL number MFCD11045969

  •  PubChem Substance ID 24890796

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Properties

Related Categories A - K, Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z,
biological source   synthetic
InChI Key   DTSOZYYWEZJFSS-XTHCGPPUSA-N
form   powder
color   white to almost white
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  mycobacteria
storage temp.   2-8°C

Description

General description

Chemical structure: aminoglycoside

Application

Amikacin hydrate is used in antimicrobial susceptibility studies of organisms such as Mycobacterium tuberculosis and Ehrlichia phagocytophila.

Biochem/physiol Actions

Amikacin inhibits bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. It interferes with the translocation of tRNA from the A-site to the P-site.

Packaging

5G

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
WK1955000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Aminoglycoside Analysis in Pork Muscle using Molecularly Imprinted Polymer Cleanup and LC/MS/MS Detection

Aminoglycosides are a well-known class of antibiotics that are routinely monitored in animal-derived foods. Many countries have instituted regulatory limits for aminoglycosides. There is growing conc...
Emily Barrey, Olga Shimelis, K. G. Espenschied
Reporter US, Volume 32.2
Keywords: Antibiotics, High performance liquid chromatography, Mass spectrometry, Separation, Size-exclusion chromatography, Solid phase extractions

Peer-Reviewed Papers
15

References

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