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A3785 Sigma-Aldrich

5-Aminolevulinic acid hydrochloride

≥98%

Synonym: δ-Aminolevulinic acid hydrochloride, 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA

  • CAS Number 5451-09-2

  • Linear Formula NH2CH2C(O)CH2CH2COOH · HCl

  • Molecular Weight 167.59

  •  Beilstein/REAXYS Number 3690651

  •  EC Number 226-679-5

  •  MDL number MFCD00012869

  •  PubChem Substance ID 24890811

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Properties

Related Categories Antitumor Agents, Cancer Research, Cell Biology, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart,
InChI Key   ZLHFONARZHCSET-UHFFFAOYSA-N
Quality Level   PREMIUM
assay   ≥98%
storage temp.   −20°C

Description

Application

5-Aminolevulinic acid hydrochloride has been used to activate or inhibit heme biosynthesis in HeLa and K562 cell lines. It has also been used in photodynamic therapy for A431 tumor bearing mice.

Packaging

1, 5 g in glass bottle

500 mg in glass bottle

Biochem/physiol Actions

5-Aminolevulinic acid (5-ALA) is an intermediate in heme biosynthesis and is useful in cancer treatment. It is a non-protein amino acid. 5-ALA also has applications in the field of agriculture. It is being studied as an inducing reagent for protoporphyrin IX (PPIX) dependent fluorescence diagnosis of metastatic lymph nodes. 5-ALA is used for photodynamic therapy of diseases, such as Paget’s disease and HPV infection-associated cervical condylomata acuminata.

Intermediate in heme biosynthesis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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