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A4034 Sigma-Aldrich

(+)-Sodium L-ascorbate

powder, BioReagent, suitable for cell culture

Synonym: L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt

  • CAS Number 134-03-2

  • Empirical Formula (Hill Notation) C6H7NaO6

  • Molecular Weight 198.11

  •  Beilstein/REAXYS Number 3767246

  •  EC Number 205-126-1

  •  MDL number MFCD00082340

  •  eCl@ss 34058010

  •  PubChem Substance ID 24890738

  •  NACRES NA.75

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Properties

Related Categories Amino Acids and Vitamins, Bioactives and Supplements for Stem Cell Expansion, Bioactives/Supplements, Cell Biology, Cell Culture,
Quality Level   200
biological source   synthetic (organic)
product line   BioReagent
assay   ≥98%
form   powder
mol wt   Mw 135.13 g/mol
application(s)   cell culture | mammalian: suitable
  cell culture | plant: suitable
color   white to off-white
mp   220 °C (dec.) (lit.)
solubility   H2O: 50 mg/mL
SMILES string   [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]
InChI   1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
InChI key   PPASLZSBLFJQEF-RXSVEWSESA-M

Description

General description

(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid). It is widely used as a food additive. In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture. Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats. sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.

Application

(+)-Sodium L-ascorbate has been used:
• to produce H2O2 in cell culture media
• as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)
• to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat

Used for preparation of plant extracts; reductant for the isolation of chloroplasts.

Packaging

1 kg in poly bottle

100, 500 g in poly bottle

Biochem/physiol Actions

Antioxidant

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
CI7671000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Related Content

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures
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Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
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Peer-Reviewed Papers
15

References

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