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A4036 Sigma-Aldrich

Adenosine

suitable for cell culture, BioReagent

Synonym: 9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside

  • CAS Number 58-61-7

  • Empirical Formula (Hill Notation) C10H13N5O4

  • Molecular Weight 267.24

  •  Beilstein/REAXYS Number 93029

  •  EC Number 200-389-9

  •  MDL number MFCD00005752

  •  eCl@ss 32160413

  •  PubChem Substance ID 24890739

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Properties

Related Categories Cell Biology, Core Bioreagents, General Reagents, Life Science Reagents for Transfection, Nutrition Research,
InChI Key   OIRDTQYFTABQOQ-KQYNXXCUSA-N
product line   BioReagent
mp   234-236 °C (lit.)
suitability   suitable for cell culture
storage temp.   2-8°C
Gene Information   human ... ADA(100), ADORA3(140), ERBB2(2064), ERBB4(2066)
rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370)

Description

General description

The nucleoside adenosine consists of the purine adenine and the sugar ribose. Thus, it is also referred as adenine-D-ribose. Adenosine is an important molecule that forms nucleotides, which is a part of nucleic acids forming the DNA and RNA. The nucleotides include: adenosine monophosphate, adenosine diphosphate and adenosine triphosphate.

Application

Adenosine has been used as a supplement in DMEM (Dulbecco′s modified Eagle medium):
• to evaluate the outgrowth of the interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts
• to maintain the CGR8 ES (germ-line competent cell line) cells
• for plasmid transfection and cloning of embryonic stem cells

Packaging

5, 25 g in poly bottle

Biochem/physiol Actions

Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).

Tissue injury, ischemia and abnormal cell proliferation stimulate the release of adenosine. Adenosine helps in countering the effects of reduced oxygen and energy in organs such as heart, brain and skeletal muscles mediating vasodialation. It delivers its action through G protein-coupled receptors. Adenosine also reduces the release of neurotransmitters and cellular metabolism.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

HPLC Analysis of Nucleosides on Ascentis® Si (HILIC Mode)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleosides on Ascentis® Si (HILIC Mode)
Keywords: Chromatography, High performance liquid chromatography

TLC Analysis of Mycotoxins on HPTLC Silica 60F 254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Mycotoxins on HPTLC Silica 60F 254s
Keywords: Agriculture, Thin layer chromatography

TLC Analysis of Nucleosides on HPTLC Silica 60 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Nucleosides on HPTLC Silica 60 F254s
Keywords: Thin layer chromatography

TLC Analysis of Nucleosides on HPTLC pre-coated plate RP-18 WF 254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Nucleosides on HPTLC pre-coated plate RP-18 WF 254s
Keywords: Agriculture, Thin layer chromatography

Peer-Reviewed Papers
15

References

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