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A4660 Sigma-Aldrich

6-Thioguanine

Hybri-Max, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Synonym: 2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol

  • CAS Number 154-42-7

  • Empirical Formula (Hill Notation) C5H5N5S

  • Molecular Weight 167.19

  •  Beilstein/REAXYS Number 157765

  •  EC Number 205-827-2

  •  MDL number MFCD00233553

  •  PubChem Substance ID 24890892

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Properties

Related Categories Cell Culture, Conditioned media supplements and reagents, Hybridoma Platform, Hybridoma Reagents, ITS and Other Supplements,
grade   Hybri-Max
InChI Key   WYWHKKSPHMUBEB-UHFFFAOYSA-N
sterility   γ-irradiated
product line   BioXtra
assay   ~98%
form   lyophilized powder
concentration   50 ×
impurities   endotoxin, tested
mp   ≥300 °C (lit.)
suitability   suitable for hybridoma

Description

Application

Used in hybridoma formation applications as a selection agent.

Biochem/physiol Actions

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Reconstitution

Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 30 μM 2-amino-6-mercaptopurine.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
UP0740000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Pipette Controller from Brand

Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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