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A5139 Sigma-Aldrich

Asp-Phe methyl ester

≥98%

Synonym: N-(L-α-Aspartyl)-L-phenylalanine methyl ester, Asp-Phe-OMe, Aspartame

  • CAS Number 22839-47-0

  • Linear Formula HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3

  • Molecular Weight 294.30

  •  Beilstein/REAXYS Number 2223850

  •  EC Number 245-261-3

  •  MDL number MFCD00002724

  •  PubChem Substance ID 24890947

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Properties

Related Categories Biochemicals and Reagents, Dipeptides, Dipeptides and Tripeptides, Peptides
InChI Key   IAOZJIPTCAWIRG-QWRGUYRKSA-N
assay   ≥98%
sweetness   160-200 × sucrose
storage temp.   2-8°C

Description

General description

Asp-Phe methyl ester (aspartame, APM, ASP), a dipeptide ester, is made up of phenyl alanine and aspartic acid. Its genotoxic effects have been investigated. Its interaction with certain hydrocolloids has been studied.

Application

Asp-Phe methyl ester is used for the preparation of Ad libitum Standard Chow, with ad libitum drinking water (animals control diet) containing Asp-Phe methyl ester. It is also used for the TFA diet preparation (TFA diet with ad lib drinking water contains Asp-Phe methyl ester.

Packaging

1, 5, 25 g in poly bottle

Biochem/physiol Actions

Asp-Phe methyl ester (Asp-Phe-OMe) is used as a synthetic sweeter, sugar substitute. Asp-Phe methyl ester is being studied for a variety of potential benefits as a nutrition supplement, such as the delay of osteoarthritis and modulation of rheumatoid factor activity. Asp-Phe methyl ester is being studied for its effect on thrombin activity and blood clotting.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
WM3407000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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