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A5330 Sigma-Aldrich

N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester

≥99% (TLC), powder

Synonym: L-732,138

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Properties

Related Categories Antagonist, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators,
assay   ≥99% (TLC)
form   powder
mp   147-148 °C (lit.)
storage temp.   −20°C
SMILES string   CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc3cc(cc(c3)C(F)(F)F)C(F)(F)F
InChI   1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
InChI key   BYYQYXVAWXAYQC-IBGZPJMESA-N
Gene Information   human ... TACR1(6869)

Description

Biochem/physiol Actions

Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC50 for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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