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A5353 Sigma-Aldrich

Apolipoprotein B from human plasma

≥95%, lyophilized powder

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Properties

Related Categories Apolipoproteins, Biochemicals and Reagents, Complex Lipids, Lipids, Plasma & Blood Proteins,
assay   ≥95%
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... APOB(338)

Description

Preparation Note

Delipidated with sodium deoxycholate.

Physical form

Lyophilized from buffer containing 10 mM sodium deoxycholate, 0.05 M sodium carbonate and 0.05 M sodium chloride, pH 10.0

Biochem/physiol Actions

Apo-B levels correlate with the risk of coronary disease. Apo-B exists in human plasma in two isoforms, Apo-B48 and Apo-B100. Apo-B100 is the major physiological ligand for the LDL receptor. Apo-B100 is a large monomeric protein, containing 4563 amino acids (MW 515 kDa). Apo-B100 is synthesized in the liver and is required for the assembly of VLDL. It does not interchange between lipoprotein particles, as do the other apolipoproteins, and it is found in IDL and LDL after the removal of the Apo-A, E, and C. Apo-B48 is present in chylomicrons and their remnants. It is essential for the intestinal absorption of dietary lipids.
Apo-B48 is synthesized in the small intestine. It comprises approximately half of the N-terminal region of Apo-B100 and is the result of posttranscriptional mRNA editing by a stop codon in the intestine not found in the liver. The concentration of Apo-B in normal plasma is ~90 mg/dl.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Webinar - Hydrogels
Protocols & Articles

Articles

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are c...
BioFiles 2007, 2.7, 13.
Keywords: Esterifications, Ligands

Omega-3 Fatty Acids and Heart Disease

The potential for the prevention and treatment of cardiovascular disease through increased dietary intake of omega-3 (w-3) fish oils is not a recent scientific discovery. A historically important stu...
BioFiles 2007, 2.2, 14.
Keywords: Anti-inflammatory agents, Biochemistry, Cardiovascular, Clinical, Degradations, Esterifications, Immunology, Inflammation, Lipid Metabolism, Metabolism, Metabolites, Methods, Nutrition, Oxidations, Transcription

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

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