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A5730 Sigma-Aldrich

Abz-SDK(Dnp)P-OH trifluoroacetate salt

≥91% (HPLC), lyophilized powder

Synonym: o-Aminobenzoic acid-Ser-Asp-Lys(DNP)P-OH trifluoroacetate salt

  • Empirical Formula (Hill Notation) C31H38N8O13 · xC2HF3O2

  • Molecular Weight 730.68 (free base basis)

  •  MDL number MFCD09753055

  •  PubChem Substance ID 24891013

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Properties

Related Categories A-AM, Angiotensin Metabolism, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥91% (HPLC)
form   lyophilized powder
solubility   H2O: freely soluble
storage temp.   2-8°C
SMILES string   OC(=O)C(F)(F)F.Nc1ccccc1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCNc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)C(=O)N3CCC[C@H]3C(O)=O
InChI   1S/C31H38N8O13.C2HF3O2/c32-19-7-2-1-6-18(19)27(43)36-23(16-40)29(45)35-22(15-26(41)42)28(44)34-21(30(46)37-13-5-9-24(37)31(47)48)8-3-4-12-33-20-11-10-17(38(49)50)14-25(20)39(51)52;3-2(4,5)1(6)7/h1-2,6-7,10-11,14,21-24,33,40H,3-5,8-9,12-13,15-16,32H2,(H,34,44)(H,35,45)(H,36,43)(H,41,42)(H,47,48);(H,6,7)/t21-,22-,23-,24-;/m0./s1
InChI key   IFSUGURCQHMSJS-JPIABUGISA-N

Description

Amino Acid Sequence

Abz-Ser-Asp-Lys-DNP

Application

Abz-SDK(Dnp)P-OH trifluoroacetate is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate that specifically binds to the N domain of ACE. Abz-SDK(Dnp)P-OH has been used to study tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells.

Packaging

1 mg in glass bottle

Biochem/physiol Actions

Abz-SDK(Dnp)P-OH is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate specific for the N domain for real time fluorescent assay (ACE, Peptidyl Dipeptidase, Kininase II, E.C. 3.4.15.1).

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Angiotensin Receptors

Different receptors/binding sites have been identified for the biologically active angiotensin (Ang) peptides, i.e. Ang II (1-8), Ang III (2-8), Ang IV (3-8) and Ang (1-7), based on the availability ...
Keywords: Atomic absorption spectroscopy, Cardiovascular, Catalysis, Cell proliferation, Gene expression, Ligands, Metabolites, Transduction

Peer-Reviewed Papers
15

References

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