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A6185 Sigma-Aldrich

Calpain Inhibitor I

≥97% (TLC), powder

Synonym: ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal

  • CAS Number 110044-82-1

  • Empirical Formula (Hill Notation) C20H37N3O4

  • Molecular Weight 383.53

  •  Beilstein/REAXYS Number 7656053

  •  MDL number MFCD00065505

  •  PubChem Substance ID 24891066

  •  NACRES NA.77

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Properties

Related Categories A to C, Aldehydes, Apoptosis Enzymes, Application Index, Bioactive Small Molecule Alphabetical Index,
Quality Level   200
biological source   synthetic (organic)
assay   ≥97% (TLC)
form   powder
color   white
solubility   DMSO: soluble
  ethanol: soluble
storage temp.   −20°C
SMILES string   [H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
InChI   1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI key   FMYKJLXRRQTBOR-BZSNNMDCSA-N
Gene Information   human ... CAPN1(823), CTSB(1508), PSMA1(5682)

Description

Application

Calpain Inhibitor I have been used:
• as a component of protease inhibitor cocktail for gel shift analysis
• for treating HeLa cell cultures
• for inhibition of 26 S proteasome in 26 S proteasome inhibition assays

Packaging

5, 25 mg in serum bottle

Biochem/physiol Actions

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..

Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase. Blocks induction of nitric oxide synthase by LPS in macrophages.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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