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A6419 Sigma-Aldrich

Adenosine 5′-triphosphate disodium salt hydrate

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

Synonym: ATP disodium salt

  • CAS Number 34369-07-8

  • Empirical Formula (Hill Notation) C10H14N5Na2O13P3 · xH2O

  • Molecular Weight 551.14 (anhydrous basis)

  •  MDL number MFCD00150755

  •  eCl@ss 32160414

  •  PubChem Substance ID 24891086

  •  NACRES NA.75

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Properties

Related Categories Cell Culture, Miscellaneous Reagents and Supplements, Reagents and Supplements More...
Quality Level   200
biological source   microbial
product line   BioReagent
assay   ≥99% (HPLC)
form   powder
application(s)   cell culture | mammalian: suitable
solubility   H2O: 50 mg/mL
storage temp.   −20°C
SMILES string   O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
InChI   1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
InChI key   NTBQNWBHIXNPRU-MSQVLRTGSA-L

Description

General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems. They are released from cells under stress and play a key role in immune response. ATP release from injured neurons and consequent breakdown leads to generation of adenosine. ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain. Elevated ATP levels are indicative of cell damage and inflammation.

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:
• as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites
• in inflammasome activation assays in bone marrow derived macrophages
• for the stimulation of macrophages
• in nucleotide synthesis

Packaging

1, 5, 10 g in poly bottle

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

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Protocols & Articles

Articles

HPLC Analysis of Adenosine Nucleosides on Supelcosil™ LC-18-T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Adenosine Nucleosides on Supelcosil™ LC-18-T
Keywords: Chromatography, High performance liquid chromatography, Separation

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Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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