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A6428 Sigma-Aldrich

Aflatoxin M1

from Aspergillus flavus

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Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Carcinogens,
Quality Level   200
biological source   Aspergillus flavus
InChI Key   MJBWDEQAUQTVKK-IAGOWNOFSA-N
storage temp.   2-8°C

Description

General description

Aflatoxins are metabolites of fungus, that are mainly seen in feeds and foods. Aflatoxin M1 is a hydroxylated metabolite of aflatoxin B1. It is liberated in milk, urine and produced in liver after receiving aflatoxin B1.

Application

Aflatoxin M1 has been used as a standard to investigate the incidence and occurrence of aflatoxin M1 (AFM1) in Brazilian milk and infant formula. It has also been used as standard to investigate the incidence and occurrence of aflatoxin M1 (AFM1) in dairy products produced in Brazil.

Aflatoxin M1 is both a hepatotoxic and hepatocarcinogenic mycotoxin that has been shown to cause immunosuppression in animals.

Biochem/physiol Actions

Aflatoxin M1 possesses hepatocarcinogenic properties.

Warning

Possibly carcinogenic.

Preparation Note

Aspergillus flavus metabolite.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

HPLC Analysis Report of Aflatoxins on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis Report of Aflatoxins on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Separation

LC/MS Analysis of Aflatoxin M1 in Milk on Ascentis® Express HILIC after SPE using Supel™ Tox AflaZea, Quantifying Picogram Concentrations

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Aflatoxin M1 in Milk on Ascentis® Express HILIC after SPE using Supel™ Tox AflaZea, Quantifying Picogram Concentrations
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Precipitation, Sample preparations, Separation, Solid phase extractions

LC/MS/MS Analysis of µLtiple Mycotoxins on Ascentis® Express Phenyl-Hexyl

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of µLtiple Mycotoxins on Ascentis® Express Phenyl-Hexyl
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

UHPLC-MS/MS Analysis of µLtiple Mycotoxins on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC-MS/MS Analysis of µLtiple Mycotoxins on Titan™ C18
Keywords: Chromatography, Clinical, Mass spectrometry

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Peer-Reviewed Papers
15

References

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