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A6476 Sigma-Aldrich

ABT-418 hydrochloride

powder, ≥98% (HPLC)

Synonym: 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride

  • CAS Number 147388-83-8

  • Empirical Formula (Hill Notation) C9H14N2O · HCl

  • Molecular Weight 202.68

  •  MDL number MFCD11045960

  •  PubChem Substance ID 24724395

  •  NACRES NA.77

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Properties

Related Categories A-AM, Abbott, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
solubility   H2O: soluble 15 mg/mL
originator   Abbott
SMILES string   Cl.CN1CCC[C@H]1c2cc(C)no2
InChI   1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
InChI key   VOXHERKWAIEJQF-QRPNPIFTSA-N

Description

Application

ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer’s disease.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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