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A6816 Sigma-Aldrich

(±)-AMPA

solid

Synonym: (±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate

  • Empirical Formula (Hill Notation) C7H10N2O4

  • Molecular Weight 186.17

  •  MDL number MFCD00213388

  •  PubChem Substance ID 24891141

  •  NACRES NA.32

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Properties

Related Categories AMPA/Kainate Agonists, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids, Ion Channels,
form   solid
color   white
solubility   H2O: 1 mg/mL (warm)
  0.1 M HCl: 3.5 mg/mL
  0.1 M NaOH: 4.3 mg/mL
  DMSO: 4.3 mg/mL
  1 M HCl: 50 mg/mL
SMILES string   O.Cc1onc(O)c1CC(N)C(O)=O
InChI   1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2
InChI key   HFISYNCCKQHIAM-UHFFFAOYSA-N
Gene Information   rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grin2a(24409), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Slc1a1(25550), Slc1a2(29482), Slc1a3(29483)

Description

Application

(±)-AMPA has been used:
• in vivo

•  whole-cell patch-clamp recording in Müller glial cells
• to test its excitotoxic effects in hippocampal slice cultures
• in retinal horizontal cells (HCs) culture to test its effect on Ca2+ signals

Packaging

1, 5, 10 mg in glass bottle

Biochem/physiol Actions

Potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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