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  • A6970 - Monoclonal Anti-Acetylcholinesterase antibody produced in mouse

A6970 Sigma

Monoclonal Anti-Acetylcholinesterase antibody produced in mouse

clone ZR3, purified immunoglobulin, buffered aqueous solution

Synonym: Monoclonal Anti-AChE



Related Categories AC-AC, Alphabetical Index, Antibodies, Antibodies for Neurobiology, Antibodies for Neurotransmission,
species reactivity   human, rabbit, rat, guinea pig, feline, mouse
application(s)   flow cytometry: 3-5 μg
  immunofluorescence: 1:20
  immunohistochemistry: 1:20
  immunoprecipitation (IP): suitable
  western blot: 1:500-1:1000
clone   ZR3, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2b
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Ache(83817)
biological source   mouse
conjugate   unconjugated



Purified rat brain acetylcholinesterase.

Physical form

Solution in 0.01 M phosphate buffered saline containing 1 mg/mL BSA and 0.05% sodium azide.

Biochem/physiol Actions

Cholinergic neurotransmission occurs in motor, autonomic and central nervous synapses and requires very rapid inactivation of its transmitter, acetylcholine (ACh). Acetylcholinesterase (AChE) rapidly hydrolyzes ACh to acetate and choline, thereby inactivating it. AChE is found in the neuromuscular junction anchored to the basal lamina which runs between the nerve terminal and muscle membrane. AChE is also found outside the nervous and neuromuscular system in blood, lymph, germ and liver cells suggesting a role for AChE not related to cholinergic transmission. Another less specific cholinesterase, butyrylcholinesterase (BChE), seems to contribute to the regulation of the ACh concentration in the synaptic cleft.

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Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
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Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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