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A6981 Sigma-Aldrich

Acamprosate calcium

≥98% (HPLC), powder

Synonym: 3-(Acetylamino)-1-propanesulfonic acid calcium salt (2:1)

  • CAS Number 77337-73-6

  • Empirical Formula (Hill Notation) C5H10Ca0.5NO4S

  • Molecular Weight 200.24

  •  EC Number 278-665-3

  •  PubChem Substance ID 329770909

  •  NACRES NA.77

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Properties

Related Categories A-AM, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
solubility   H2O: >5 mg/mL
storage temp.   room temp
SMILES string   CC(=O)NCCCS(=O)(=O)O[Ca]OS(=O)(=O)CCCNC(C)=O
InChI   1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2
InChI key   BUVGWDNTAWHSKI-UHFFFAOYSA-L
Gene Information   human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Acamprosate calcium is a synthetic analog of γ-aminobutyric acid (GABA) and a GABAB receptor agonist. Acamprosate calcium has been used in alcohol dependence treatments and may be an effective augmentation therapy anxiety patients.

Acamprosate calcium is a GABA γ-aminobutyric acid agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

GABAA Receptors

GABAA receptors are responsible for the majority of neuronal inhibition in the mammalian CNS. Agonist activation results in the opening of their integral anion channel, generally leading to hyperpola...
Keywords: Anticonvulsants, Central Nervous System, Cloning, Gene expression, Ligands, Neurotransmitters, Phosphorylations, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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