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A7231 Sigma-Aldrich

AZ11645373

≥98% (HPLC), solid

Synonym: 3-[1-[[(3′-nitro[1,1′-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

  • CAS Number 227088-94-0

  • Empirical Formula (Hill Notation) C24H21N3O5S

  • Molecular Weight 463.51

  •  NACRES NA.77

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Description

Application

AZ11645373 is a selective and potent human P2X7 purinoceptor antagonist. AZ11645373 has been used in the rhesus macaque monkey to elucidate the mechanisms and pharmacological interventions of P2X7 receptor-related diseases.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

AZ11645373 is a selective and potent human P2X7 purinoceptor antagonist. KB values range from 5-20 nM for human P2X7 receptor inhibition. It is 500-fold less effective ats an inhibitor of rat P2X7 receptor responses.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

P2 Receptors: P2X Ion Channel Family

Once known as P2 purinoreceptors, surface receptors for extracellular nucleotides are now called P2 receptors. This subtle change in nomenclature reflects the more varied nature of nucleotidic ligand...
Keywords: Apoptosis, Atomic absorption spectroscopy, Gene expression, Inflammation, Ligands, Magnetic resonance spectroscopy, Polymorphisms, Transcription, Transduction

Peer-Reviewed Papers
15

References

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