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A7236 Sigma-Aldrich

Anacardic acid

Synonym: 2-Hydroxy-6-pentadecylbenzoic acid, 22:0-Anacardic acid, 6-Pentadecylsalicylic acid

  • CAS Number 16611-84-0

  • Empirical Formula (Hill Notation) C22H36O3

  • Molecular Weight 348.52

  •  MDL number MFCD07368254

  •  PubChem Substance ID 329770923

  •  NACRES NA.77

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Properties

Related Categories AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Cell Biology,
form   powder
storage condition   protect from light
color   white to beige
solubility   DMSO: ≥20 mg/mL
storage temp.   −20°C
SMILES string   CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O
InChI   1S/C22H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h15,17-18,23H,2-14,16H2,1H3,(H,24,25)
InChI key   ADFWQBGTDJIESE-UHFFFAOYSA-N

Description

Application

Anacardic acid is a histone acetyltransferase (HAT) inhibitor. Anacardic acid has bactericide, fungicide, insecticide, anti-termite and molluscicide properties and acts as a therapeutic agent in the treatment of pathophysiological disorders such as cancer, oxidative damage, inflammation and obesity. Anacardic acid is a common inhibitor of several clinically targeted enzymes such as NFκB kinase, histone acetyltransferase (HATs), lipoxygenase (LOX-1), xanthine oxidase, tyrosinase and ureases.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Anacardic acid is a HAT (Histone Acetyltransferase) inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Gene Regulation

The loss of regulation of gene expression is a key component to many human disease states, including neurodegenerative disorders, autoimmune conditions and, most prominently, cancers. Regulation of g...
Keywords: Acetylations, Epigenetics, Gene expression, Genomics, Methylations, PAGE, Post translational modifications, Transcription

Histone Modification and Chromatin Remodeling

Gene expression is governed by complex mechanisms including transcription factor binding to DNA and coordinated changes in chromatin structure. The primary protein components of chromatin are the his...
Savita Bagga, PhD.
BioFiles v7 n3, 2012, 10–16
Keywords: Acetylations, Amplification, Cancer, Cell culture, Chromatin immunoprecipitation, Cloning, DNA purification, Diseases, Epigenetics, Gene expression, Immunoprecipitation, Indicators, Methylations, Microarray Analysis, Polymerase chain reaction, Polymerase chain reaction - quantitative, Polymorphisms, Purification, Sequencing, Transcription, Whole genome amplification

Peer-Reviewed Papers
15

References

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EPI001 Histone Acetyltransferase (HAT) Activity Assay Kit, 100 assays in 96 well plates

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