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A7475 Sigma-Aldrich

Anthopleurin-A

>88% (HPLC)

Synonym: AP-A, Anthopleura toxin A

  • CAS Number 60880-63-9

  • Empirical Formula (Hill Notation) C220H326N64O67S6

  • Molecular Weight 5131.72

  •  MDL number MFCD00240628

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Description

Amino Acid Sequence

Gly-Val-Ser-Cys-Leu-Cys-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Thr-Leu-Trp-Leu-Tyr-Pro-Ser-Gly-Cys-Pro-Ser-Gly-Trp-His-Asn-Cys-Lys-Ala-His-Gly-Pro-Thr-Ile-Gly-Trp-Cys-Cys-Lys-Gln [Disulfide bridges: 4-46, 6-36, 29-47]

General description

Synthetic peptide toxin that was originally isolated from the sea anemone, Anthopleura xantho­grammica.

Application

Anthopleurin-A is a toxin used to study the gating mechanisms of sodium channels. Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.

Biochem/physiol Actions

Shown to have inotropic effects and not chronotropic effects on mammalian heart preparations.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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