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A7603 Sigma-Aldrich

Aculeacin A

from Aspergillus aculeatus, ≥95% (HPLC)

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action, Antifungal, Biochemicals and Reagents,
biological source   Aspergillus aculeatus
InChI Key   YKPHLXGEPNYRPY-ZIUFDZNVSA-N
assay   ≥95% (HPLC)
form   powder
solubility   DMSO: 10 mg/mL
  DMF: soluble
  ethanol: soluble
  methanol: soluble
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   yeast
shipped in   wet ice
storage temp.   −20°C

Description

Application

Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae , the inhibition of Candida albicans, and the morphogenetic transformation of Candida albicans when treated .

Packaging

1 mg in glass bottle

Biochem/physiol Actions

Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase.

Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β−glucan by selective blockage of β(1→3) glucan synthase.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
AU2980000

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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