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A7606 Sigma-Aldrich

Aprindine hydrochloride

≥98% (HPLC), solid

Synonym: N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride, Amidonal

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Properties

Related Categories AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   solid
solubility   H2O: >10 mg/mL
storage temp.   2-8°C
SMILES string   Cl.CCN(CC)CCCN(C1Cc2ccccc2C1)c3ccccc3
InChI   1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H
InChI key   KIPFVRHNAAZJOD-UHFFFAOYSA-N

Description

Application

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
TX7386000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Potassium Channels

Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing

Peer-Reviewed Papers
15

References

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