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A8016 Sigma-Aldrich

Adenosine 5′-[β-thio]diphosphate trilithium salt

≥80% (HPLC)

Synonym: ADP-β-S, Adenosine-5′-0-(2-thiodiphosphate) trilithium salt, Ado-5′-PP[S]

  • CAS Number 73536-95-5

  • Empirical Formula (Hill Notation) C10H12Li3N5O9P2S

  • Molecular Weight 461.07

  •  MDL number MFCD00077314

  •  eCl@ss 32160414

  •  PubChem Substance ID 24891307

  •  NACRES NA.77

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Properties

Related Categories A-AM, Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   CPKFUAYUUSSFFZ-MSQVLRTGSA-K
  CPKFUAYUUSSFFZ-MSQVLRTGSA-K
Quality Level   200
assay   ≥80% (HPLC)
storage temp.   −20°C

Description

Application

Adenosine 5′-[β-thio]diphosphate is a substrate and inhibitor for AMP dependent enzyme systems. Adenosine 5′-[β-thio]diphosphate has been used to explore the myenteric control mechanisms of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters.

Adenosine 5′-[β-thio]diphosphate trilithium salt has been used to induce neuropathic pain in rats to study the effect of dorsal horn cannabinoid CB2 receptor activation on the expression of P2Y12 and P2Y13 (purinoceptors) receptors.

Biochem/physiol Actions

P2Y receptor agonist.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Non-hydrolyzable ADP analog

Substrates

Substrate and inhibitor for AMP dependent enzyme systems.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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