A8094 Sigma-Aldrich


from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Synonym: (S)-2-Amino-5-guanidinopentanoic acid

  • CAS Number 74-79-3

  • Linear Formula H2NC(=NH)NH(CH2)3CH(NH2)CO2H

  • Molecular Weight 174.20

  •  Beilstein/REAXYS Number 1725413

  •  EC Number 200-811-1

  •  MDL number MFCD00002635

  •  eCl@ss 32160406

  •  PubChem Substance ID 24891316



Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acids, Amino Acids & Derivatives,
Quality Level   200
biological source   non-animal source
Agency/Method   meets EP testing specifications
  meets USP testing specifications
assay   98.5-101.0%
form   powder
application(s)   cell culture | mammalian: suitable
  peptide synthesis: suitable
impurities   endotoxin, tested
color   white
mp   222 °C (dec.) (lit.)
solubility   H2O: 100 mg/mL
Featured Industry   Agriculture
Pharmaceutical (small molecule)
SMILES string   N[C@@H](CCCNC(N)=N)C(O)=O
InChI   1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
Gene Information   human ... NOS1(4842), NOS2(4843)
rat ... Ppm1a(24666)



L-Arginine has been used:
• as a Roswell park memorial institute medium (RPMI) media component in the isolation and culture of peripheral blood mononuclear cells (PBMCs)
• as a RPMI media component for tissue culture
• in DMEM medium for the identification and quantification of phosphorylation sites by stable isotope labeling by amino acids in cell culture (SILAC) and LCMS/MS


1 kg in poly bottle

10 mg in glass bottle

25, 100 g in poly bottle

Biochem/physiol Actions

L-Arginine is a conditionally essential amino acid, that play a vital role in the production of nitric oxide. It acts as a precursor for the synthesis of polyamines, agmatine and urea. L-Arginine is usually essential in children and non-essential in adults.

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


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Protocol Guide: XTT Assay for Cell Viability and Proliferation

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Keywords: Antibiotics, Cell proliferation, Enzyme-linked immunosorbent assay, Growth factors, Indicators, Metabolism, Reductions

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