• USA Home
  • A8344 - Anti-ARC, C-Terminal antibody produced in rabbit

A8344 Sigma

Anti-ARC, C-Terminal antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Apoptosis Repressor with CARD



Related Categories AR-AR, Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology,
species reactivity   human
application(s)   microarray: suitable
  western blot: 1:1,000 using HeLa cell extract
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 22 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... NOL3(8996)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 191-208 of human ARC (apoptosis repressor with CARD).

General description

ARC is part of the activity regulated cytoskeleton-associated protein family. It is involved in endocytosis of AMPA receptors and formation of long-term memory. It is found expressed in the cytoplasma of neuronal dendrites.

ARC protein contains an N-terminal CARD that has homology to the CARDs present in Apaf-1 and RAIDD. It binds to and inhibits the activity of caspase 8. It also binds to caspase 9 and to Ced-3. It inhibits apoptosis induced by death receptors that require caspase 8 activation.

Rabbit Anti-ARC, C-Terminal antibody binds to amino acids 191-208 of human ARC.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.


Rabbit Anti-ARC, C-Terminal antibody can be used for western blot (1:1,000) and microarray analyses.

Price and Availability

Your Key to Success

Antibody Explorer

Explore with Confidence
Safety & Documentation

Safety Information

WGK Germany  3
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?