• USA Home
  • A8346 - ProteoMass ACTH Fragment 18-39 MALDI-MS Standard

EMAIL THIS PAGE TO A FRIEND
A8346 Sigma-Aldrich

ProteoMass ACTH Fragment 18-39 MALDI-MS Standard

vial of 10 nmol, monoisotopic mol wt 2,464.1989 Da

Synonym: Adrenocorticotropic hormone fragment 18-39

Purchase

Properties

Related Categories Mass Spectrometry, Molecular Biology, Peptide and Protein Standards for Mass Spectrometry Analysis, Proteomics
Quality Level   100
mol wt   monoisotopic mol wt 2,464.1989 Da
packaging   vial of 10 nmol
SMILES string   CC(C)CC(NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(Cc4ccc(O)cc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(C)C)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(Cc6ccccc6)C(O)=O
InChI   1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)
InChI key   ZYDMZKPAPSZILB-UHFFFAOYSA-N

Description

Amino Acid Sequence

Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

General description

The single peptide or protein standard is used to calibrate and test matrix assisted laser desorption ionization (MALDI) mass spectrometers. Adrenocorticotropic hormone (ACTH) is synthesized from its precursor pro-opiomelanocortin (POMC). It is released from anterior pituitary gland in response to corticotropin-releasing hormone (CRH) from hypothalamus.

Application

Peptide calibration standard for MALDI-MS instruments; 1 vial contains 10 nmols.
ProteoMass ACTH fragment 18-39 MALDI-MS standard has been used as a peptide calibration standard for matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) instruments.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) stimulates the synthesis and release of glucocorticoids and androgens through cAMP-dependent by a G-protein coupled receptor in adrenal gland. Overproduction of ACTH leads to marked skin pigmentation.

Storage and Stability

Each standard is stored at room temperature and is shipped at ambient temperature. Standard stock solutions can be frozen in aliquots, but should not be subjected to more than 3 freeze-thaw cycles. Standard solutions are recommended for use for no longer than one month after reconstitution.

Legal Information

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles

Articles

Ultra-pure MALDI Matrices

One of the most important aspects of our ultra-pure MALDI matrix substances is their ability to dissolve rapidly and completely; a brief vortex mixing is typically sufficient. Actual performance of t...
Monika Baeumle, Alex Rueck
Analytix Volume 7 Article 5
Keywords: Crystallization, Digestions, High performance liquid chromatography, Mass spectrometry, Phase transitions, Proteomics, Sample preparations

Related Content

Stable Isotope-labeled MS Internal Standards

What happens when you combine state-of-the-art technology with scientific prowess? Full-length protein standards with the highest purity and isotopic incorporation in the industry. Stable isotope-lab...
Keywords: Atomic absorption spectroscopy, Buffers, Digestions, Mass spectrometry, PAGE, Phosphorylations, Proteomics

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

04973 Micro-Array for Mass Spectrometry (MAMS), for quantitative MALDI

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?