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A8937 Sigma-Aldrich

Adenosine 5′-triphosphate dipotassium salt hydrate

from microbial, ≥92% (HPLC)

Synonym: 5′-ATP-K2

  • CAS Number 42373-41-1 (anhydrous)

  • Empirical Formula (Hill Notation) C10H14K2N5O13P3 · xH2O

  • Molecular Weight 583.36 (anhydrous basis)

  •  eCl@ss 32160414

  •  PubChem Substance ID 24891383

  •  NACRES NA.51

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Properties

Related Categories Biochemicals and Reagents, Nucleosides, Nucleotides, Oligonucleotides, Nucleotides More...
biological source   microbial
assay   ≥92% (HPLC)
solubility   H2O: 50 mg/mL
storage temp.   −20°C
SMILES string   [K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

Description

General description

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.

Application

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:
•  in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
• as a component of energy solution for calibrating crude cell extract
• to test its dependency with PK11195 in mediating autophagy

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems.

Caution

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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