A9041 Sigma


≥95% (HPLC)



Amino Acid Sequence


General description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.

RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ß1 (TGFß1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages

Other Notes

Lyophilized from 0.1% TFA in H2O


Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

This product is soluble in water (1 mg/ml), yielding a
clear, colorless solution.

Price and Availability

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.1 Nonetheless, major challenges still need ...
Masamichi NakayamaTeruo Okano and Françoise M. Winnik
Material Matters 2010, 5.3, 56.
Keywords: Adhesion, Applications, Biomaterials, Cell culture, Clinical, Dehydration reaction, Growth factors, Hydration reaction, Immobilization, Inflammation, Ligands, Magnetic resonance spectroscopy, Material Matters, Polymerization reactions, Radical polymerization, Rearrangements, Reversible addition-fragmentation chain transfer polymerizations, Solvents

Peer-Reviewed Papers


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