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  • AV31990 - Anti-INSM1 antibody produced in rabbit

AV31990 Sigma-Aldrich

Anti-INSM1 antibody produced in rabbit

IgG fraction of antiserum

Synonym: Anti-Insulinoma-associated 1

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, Antibodies for Epigenetics and Nuclear Signaling, Antibodies to Transcription Factors, HO - L999,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: suitable
species reactivity   human, mouse, bovine, dog, pig
mol wt   53 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
antibody product type   primary antibodies
concentration   0.5 mg - 1 mg/mL
NCBI accession no.   NP_002187
UniProt accession no.   Q01101
Gene Information   human ... INSM1(3642)


General description

Insulinoma-associated 1 (INSM1/IA-1) is a zinc-finger transcription factor restrictedly expressed in pancreatic β-cells during early pancreas development. INSM1/IA-1 regulates NeruoD1/β2 and insulin gene expression during β-cell maturation. INSM1 transcription factor, an important player in early embryonic neurogenesis, contributes to endocrine and neuroendocrine cell differentiation.

Rabbit polyclonal anti-INSM1 antibody reacts with canine, bovine, human, mouse, rat, and zebrafish Insulinoma-associated 1 transcription factors.


Synthetic peptide directed towards the middle region of human INSM1


Rabbit Anti-INSM1 antibody can be used for western blot assays at a concentration of 1.25μg/ml. The antibody can also be used for IHC at 4-8μg/ml using paraffin-embedded tissues.

Rabbit polyclonal anti-INSM1 antibody is used to tag Insulinoma-associated 1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of Insulinoma-associated 1 in endocrine and neuroendocrine cell differentiation.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.


Synthetic peptide located within the following region: PAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPV

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

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Western Blot Protocol | Immunoblotting Protocol

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