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  • AV43827 - Anti-SLC1A4 antibody produced in rabbit

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AV43827 Sigma-Aldrich

Anti-SLC1A4 antibody produced in rabbit

affinity isolated antibody

Synonym: Anti-ASCT1, Anti-SATT, Anti-Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies to Drug Transport Proteins, Biochemicals and Reagents, Drug Transport Proteins & Reagents,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: suitable
  western blot: suitable
species reactivity   guinea pig, rat, dog, mouse, rabbit, human
mol wt   56 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
Quality Level   100
concentration   0.5 mg - 1 mg/mL
NCBI accession no.   NP_001129053
UniProt accession no.   P43007
Gene Information   human ... SLC1A4(6509)

Description

General description

Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (ASCT1, SATT, SLC1A4) is a sodium dependent concentrative transporter of neutral amino acids such as alanine, glutamate, serine, cysteine and the imino acids, hydroxyproline and proline. Defective SLC1A4 has been linked to multiple system atrophy (MSA), an adult-onset sporadic neurodegenerative disease.

Specificity

Anti-SLC1A4 polyclonal antibody reacts with bovine, human, mouse, rat, chicken, and zebrafish solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 proteins.

Immunogen

Synthetic peptide directed towards the C terminal region of human SLC1A4

Application

Anti-SLC1A4 polyclonal antibody is used to tag solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 in the concentrative uptake of neutral amino acids such as alanine, glutamate, serine, cysteine and the imino acids, hydroxyproline and proline.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

SLC1A4 is a transporter for alanine, serine, cysteine, and threonine. It exhibits sodium dependence.

Sequence

Synthetic peptide located within the following region: ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKES

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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