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  • AV49648 - Anti-CDH22 antibody produced in rabbit

AV49648 Sigma-Aldrich

Anti-CDH22 antibody produced in rabbit

IgG fraction of antiserum

Synonym: Anti-C20orf25, Anti-Cadherin-like 22, Anti-MGC39564, Anti-dJ998H6.1

  •  NACRES NA.41



conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: suitable
species reactivity   mouse, human, rat, dog, guinea pig, horse, rabbit, bovine
mol wt   73 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
Quality Level   100
antibody product type   primary antibodies
concentration   0.5 mg - 1 mg/mL
NCBI accession no.   NP_067071
UniProt accession no.   Q9UJ99
Gene Information   human ... CDH22(64405)


General description

Cadherin 22, type 2 (CDH22) belongs to cadherin family. Cadherins are transmembrane proteins. They contain an extracellular domain responsible for cell-cell binding, a transmembrane domain and a cytoplasmic domain.


Synthetic peptide directed towards the N terminal region of human CDH22


Anti-CDH22 antibody produced in rabbit is suitable for western blotting at a concentration of 5.0μg/ml.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Cadherin 22, type 2 (CDH22) is a calcium-dependent cell adhesion protein expressed highly in the brain. Functions of CDH22 include morphogenesis in neural and non-neural cells during the development of brain and the neuroendocrine organs. CDH22 interacts directly with PRL3 (Protein-tyrosine phosphatase of regenerating liver 3), gene responsible for promotion of epithelial mesenchymal transition. PRL3 results in down-regulation of CDH22 expression. CDH22 is up-regulated in colorectal cancer and lymphatic metastasis of colorectal carcinoma. Absence of CDH22 partially suppresses proliferation of colorectal cancer cells.


Synthetic peptide located within the following region: LIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQD

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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