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B1401 Sigma-Aldrich

Bradykinin Fragment 1-5

≥97% (HPLC)

  • CAS Number 23815-89-6

  • Empirical Formula (Hill Notation) C27H40N8O6

  • Molecular Weight 572.66

  •  MDL number MFCD00076260

  •  PubChem Substance ID 24891591

  •  NACRES NA.32

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Properties

Related Categories Bradykinins, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
assay   ≥97% (HPLC)
storage temp.   −20°C
SMILES string   NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O
InChI   1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)
InChI key   USSUMSBPLJWFSZ-UHFFFAOYSA-N
Gene Information   human ... KNG1 (includes EG:3827)(3827)

Description

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Peptides on Discovery® BIO Wide Pore C18 (PFPA Mobile Phase Additive)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Peptides on Discovery® BIO Wide Pore C18 (PFPA Mobile Phase Additive)
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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