B150 Sigma-Aldrich


≥99%, sodium salt, lyophilized powder

  • CAS Number 136553-81-6

  • Empirical Formula (Hill Notation) C31H41N6O7 Na

  • Molecular Weight 632.68

  •  MDL number MFCD00133204

  •  PubChem Substance ID 24891595

  •  NACRES NA.32



Related Categories Antagonists, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Endothelin - Receptor Antagonists,
Quality Level   200
assay   ≥99%
form   lyophilized powder
storage temp.   −20°C
SMILES string   [H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C
InChI   1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
Gene Information   human ... EDNRA(1909), EDNRB(1910)
rat ... Ednra(24326), Ednrb(50672)


Amino Acid Sequence



BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Biochem/physiol Actions

BQ-123 is an endothelin(Et) receptor antagonist and is exquisite for endothelin A (ETA) receptor. It is a cyclic pentapeptide.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How should Product B150, BQ-123, be dissolved?
This product is soluble in water (0.25mg/ml), yielding a clear colorless solution.
IsProduct B150 the free acid form of BQ-123, or is it a salt?
Product No. B150 is BQ123 sodium salt.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solution stability for Product B150, BQ-123?
We do not perform any solution stability studies on Product B150, BQ-123.The following reference indicates that the product is stable in solution for 24 hours but no temperature was mentioned. Cardillo, C. et al., Hypertension, 33, 753-758 (1999). The following abstract indicates that BQ-123 was used in an osmotic pump for a 2 week treatment. Bonvollet, S. et al., A.J.P. - Heart,266 (4), H1327-H1331 (1994).
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