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B1552 Sigma-Aldrich

Bromoenol lactone

≥98% (TLC)

Synonym: BEL, E-6-(Bromoethylene)tetrahydro-3-(1-naphthyl)-2H-pyran-2-one

  • CAS Number 88070-98-8

  • Empirical Formula (Hill Notation) C16H13BrO2

  • Molecular Weight 317.18

  •  MDL number MFCD00270871

  •  PubChem Substance ID 24278257

  •  NACRES NA.77

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Properties

Related Categories A to C, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   200
biological source   synthetic (organic)
assay   ≥98% (TLC)
form   powder
potency   636 nM Ki
solubility   DMSO: soluble (Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.)
  degassed ethanol: soluble (Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.)
λmax   224 nm
storage temp.   −20°C
SMILES string   [H]\C(Br)=C1\CCC(C(=O)O1)c2cccc3ccccc23
InChI   1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+
InChI key   BYUCSFWXCMTYOI-ZRDIBKRKSA-N

Description

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Potent, irreversible inhibitor of calcium-independent phospholipase A2 and of magnesium-dependent phosphatidate phosphohydrolase from P388D macrophages (IC50 = 8 μM); enzyme activated irreversible chymotrypsin inhibitor (Ki = 636 nM).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers
15

References

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