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B2754 Sigma-Aldrich

Betaine monohydrate

≥99%

  • CAS Number 590-47-6

  • Linear Formula (CH3)3N+CH2COO- · H2O

  • Molecular Weight 135.16

  •  Beilstein/REAXYS Number 3626258

  •  EC Number 209-684-7

  •  MDL number MFCD00150010

  •  PubChem Substance ID 24891670

  •  NACRES NA.83

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Properties

Related Categories A to C, Biochemicals and Reagents, Cholinesterase, butyryl, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   200
biological source   synthetic
assay   ≥99%
form   powder or crystals
solubility   water: 50 mg/mL, clear, colorless
storage temp.   2-8°C
SMILES string   O.C[N+](C)(C)CC([O-])=O
InChI   1S/C5H11NO2.H2O/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H2
InChI key   NJZRLXNBGZBREL-UHFFFAOYSA-N

Description

General description

Betaine is a zwitterionic quaternary ammonium compound and is mainly present in animals, microorganisms and plants. It is one of the main constituent of several food items like wheat, shellfish, spinach and sugar beets. It is also termed as trimethylglycine, lycine, glycine betaine and oxyneurine. Betaine is a methyl derivative of glycine. It has a molecular mass of 117.2.

Application

Betaine monohydrate has been used:
• in the preparation of KLA buffer to perform polymerase chain reaction (PCR)
• to study the its effects on Km and Vmax of human aldose reductase
• to study its effects on the growth of A549 lung cancer both in vitro and in vivo

Biochem/physiol Actions

Betaine, as an osmolyte helps to guard the cells, proteins and enzymes from environmental stress. It also acts as a methyl donor to involve in the methionine cycle.

End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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