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B2809 Sigma-Aldrich

Bactenecin

≥95% (HPLC)

  • Empirical Formula (Hill Notation) C63H118N24O13S2

  • Molecular Weight 1483.89

  •  MDL number MFCD00236810

  •  PubChem Substance ID 329773208

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Biochemicals and Reagents,
InChI Key   RHISNKCGUDDGEG-CJMCYECYSA-N
assay   ≥95% (HPLC)
form   powder
solubility   1 mg/mL (in 1% TFA in H20)
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
storage temp.   −20°C

Description

Amino Acid Sequence

Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg-OH (Disulfide bridge: 3-11)

Other Notes

Peptide antibiotic, originally isolated from bovine neutrophil granules

Keep container tightly closed in a dry and well-ventilated place.

Application

Bactenecin′s activity has been studied as a cyclic molecule as well as in a linear form. It was used to study the functional role of Trk1p in the mechanism of other antifungal peptides. It has been used to study chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components.

Biochem/physiol Actions

Bactenecin is a 12-amino acid cationic antimicrobial peptide from bovine neutrophils. It strongly binds to LPS and perturbs the structure, fluidity and permeability of the inner membrane. This results in the leakage of cytosol and subsequent death of the bacteria.

General description

Chemical structure: peptide

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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