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B3061 Sigma-Aldrich

Borrelidin

from Streptomyces parvulus, ≥98% (HPLC)

Synonym: 2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecarboxylic acid, Borrelidine, Cyclopentanecarboxylic acid, NSC 216128, Treponemycin

  • CAS Number 7184-60-3

  • Empirical Formula (Hill Notation) C28H43NO6

  • Molecular Weight 489.64

  •  MDL number MFCD01740784

  •  PubChem Substance ID 24724417

  •  NACRES NA.77

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
Quality Level   200
biological source   Streptomyces parvulus
assay   ≥98% (HPLC)
solubility   DMSO: 1 mg/mL
  methanol: 1 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
shipped in   wet ice
storage temp.   −20°C
SMILES string   [H][C@]1(CCC[C@H]1C(O)=O)[C@@H]2C\C=C\C=C(C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O2
InChI   1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25-,27+/m0/s1
InChI key   OJCKRNPLOZHAOU-UGKRXNSESA-N

Description

General description

Chemical structure: macrolide

Biochem/physiol Actions

Borrelidin is a potent angiogenesis inhibitor that induces apoptosis in capillary tube-forming cells. Also displays antimalarial activity against drug-resistant Plasmodia. Antimicrobial and selective threonyl t-RNA synthetase inhibitor.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
ED8750000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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