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B3501 Sigma-Aldrich

Betaine hydrochloride

≥99%

Synonym: (Carboxymethyl)trimethylammonium hydrochloride

  • CAS Number 590-46-5

  • Linear Formula (CH3)3N+CH2COOH · Cl-

  • Molecular Weight 153.61

  •  Beilstein/REAXYS Number 3916181

  •  EC Number 209-683-1

  •  MDL number MFCD00011903

  •  PubChem Substance ID 24278266

  •  NACRES NA.77

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Properties

Related Categories A to C, Biochemicals and Reagents, Cell Biology, Cholinesterase, butyryl, Enzyme Inhibitors,
Quality Level   100
biological source   synthetic (organic)
assay   ≥99%
form   powder or crystals
mp   241-242 °C (lit.)
solubility   water: 50 mg/mL, clear, colorless
storage temp.   room temp
SMILES string   [Cl-].C[N+](C)(C)CC(O)=O
InChI   1S/C5H11NO2.ClH/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H
InChI key   HOPSCVCBEOCPJZ-UHFFFAOYSA-N
Gene Information   human ... BHMT(635), BHMT2(23743)

Description

General description

Betaine (trimethyl glycine) is an osmoprotectant, which is highly effective than proline. It is formed in from choline. Betaine is usually present in grains, spinach, beets, broccoli, shellfish and marine algae.

Application

Betaine hydrochloride has been used as a component of fixative in HEPES or cacodylate buffer to improve preservation of the ultrastructural morphology of human spermatozoa.

Packaging

1 kg in poly bottle

100, 250 g in poly bottle

Biochem/physiol Actions

Betaine hydrochloride can decrease hepatotoxicity, that is stimulated by ethanol.

End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
BP3136000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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