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B3811 Sigma-Aldrich

B-9430 trifluoroacetate salt

≥98% (HPLC)

Synonym: D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp3, Igl5, D-Igl7, Oic8]-Bradykinin trifluoroacetate salt

  • CAS Number 180981-09-3 (free base)

  • Empirical Formula (Hill Notation) C64H95N19O13 · xC2HF3O2

  • Molecular Weight 1338.56 (free base basis)

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Properties

Related Categories Biochemicals and Reagents, Bradykinins, Bradykinnins - Receptor Antagonists, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
storage condition   protect from light
  protect from light
  under inert gas
solubility   H2O: ≥2 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

Biochem/physiol Actions

B-9430 was developed by Gera at the Stewart laboratory1 and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA2 = 8.6) and B1 receptors (pA2 = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

Caution

Product is air and light sensitive. Store in the dark.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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