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B4388 Sigma-Aldrich

2-Bromo-2-chloro-1,1,1-trifluoroethane

≥99%

Synonym: Halothane

  • CAS Number 151-67-7

  • Linear Formula BrCH(Cl)CF3

  • Molecular Weight 197.38

  •  Beilstein/REAXYS Number 1736947

  •  EC Number 205-796-5

  •  MDL number MFCD00009602

  •  PubChem Substance ID 24891772

  •  NACRES NA.77

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents, Enzyme Inhibitors, Neurobiology,
vapor pressure   4.5 psi ( 20 °C)
assay   ≥99%
contains   0.01% thymol as stabilizer
refractive index   n20/D 1.369 (lit.)
bp   50.2 °C (lit.)
density   1.872 g/mL at 25 °C (lit.)
SMILES string   FC(F)(F)C(Cl)Br
InChI   1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
InChI key   BCQZXOMGPXTTIC-UHFFFAOYSA-N
Gene Information   human ... ATP5D(513), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GLRA1(2741), GLRB(2743), GRIA1(2890), KCNK10(54207), KCNK18(338567), KCNK2(3776), KCNK3(3777), KCNK9(51305), KCNN4(3783)

Description

Application

2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.

Packaging

125, 250 mL in glass bottle

Biochem/physiol Actions

Inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
UN 3334
WGK Germany 
WGK 3
RTECS 
KH6550000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Single- & multi-channel pipettes from BRAND
Protocols & Articles
Peer-Reviewed Papers
15

References

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