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B5063 Sigma-Aldrich

BMS-193885

≥98% (HPLC)

Synonym: 1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-dimethyl ester-3,5-pyridinedicarboxylic acid

  • CAS Number 186185-03-5

  • Empirical Formula (Hill Notation) C33H42N4O6

  • Molecular Weight 590.71

  •  MDL number MFCD16878998

  •  PubChem Substance ID 329773248

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Bristol-Myers Squibb,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   light yellow to yellow
solubility   DMSO: >10 mg/mL
originator   Bristol-Myers Squibb
storage temp.   −20°C
SMILES string   COC(=O)C1=C(C)NC(C)=C(C1c2cccc(NC(=O)NCCCN3CCC(CC3)c4cccc(OC)c4)c2)C(=O)OC
InChI   1S/C33H42N4O6/c1-21-28(31(38)42-4)30(29(22(2)35-21)32(39)43-5)25-10-6-11-26(19-25)36-33(40)34-15-8-16-37-17-13-23(14-18-37)24-9-7-12-27(20-24)41-3/h6-7,9-12,19-20,23,30,35H,8,13-18H2,1-5H3,(H2,34,36,40)
InChI key   WMYSXJSJXZFODY-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BMS-193885 is a potent, selective Y1 antagonist that is active in both acute and chronic animal models of food intake. Although it is active in vivo, it is not orally bioavailable due to poor intestinal absorption, so it is not being pursued for pharmaceutical development. BMS-193885 has been used as a pre-clinical proof of concept tool for showing efficacy of Y1 antagonism in treating obesity.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Neuropeptide Y Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Neuropeptide Y Receptors

Neuropeptide Y (NPY), a 36 amino acid peptide and one of the most abundant peptides found in the mammalian brain, shares high sequence homology with peptide YY (PYY) and the pancreatic polypeptides (...
Keywords: Atomic absorption spectroscopy, Gastrointestinal, Gene expression, Hormones, Neurotransmitters, Obesity, Reductions, Respiratory, Transduction

Peer-Reviewed Papers
15

References

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